Enzalutamide

What Is Enzalutamide?

Enzalutamide is the preferred prescription medicine that is used for treating prostate cancer in men.

The medicine is prescribed for men who receive hormone therapy or surgery for lowering testosterone.

The enzalutamide is also widely used if the cancer treatment is no longer responding. The enzalutamide is also widely helpful for avoiding the spread of cancer cells in the body.

The effect of enzalutamide is not safe for females and women. Xtandi is normally the androgen receptor inhibitor, which is useful for treating prostate cancers.

The xtandi works by easily preventing the action of the Androgens or male hormones.

 These are the best medicines when prostate cancer is no longer responding to surgical treatment or hormone therapy.

Xtandi is also a suitable option for avoiding the spread of cancer cells to other parts of the body.

These are significant options for controlling cancer cell growth along with decreasing the Tumour size. Knowing the xtandi uses before taking the medication is quite helpful.

Xtandi is used for patients with having high risk of cancer spreading to other parts of the body. Normally, the Xtandi is the most commonly used FDA-approved medicine.

How Does Enzalutamide Work?

Enzalutamide is the Androgen Receptor (AR) inhibitor to easily make the complete Castration-Resistant Prostate Cancer (CRPC) treatments.

 These involve both the metastatic and non-metastatic.

 Normally, xtandi involves the second-generation antiandrogen agent, which is widely approved by the FDA.

The Androgen Deprivation Therapy (ADT) are also involved with first-line treatment for treating prostate cancer. It also involves the remission achieved along with raising the resistance.

ADT is also one of the treatments for castration-resistant prostate cancer.

AR inhibitors were developed for targeted therapy, and it is first-generation AR inhibitors.

 Prostate cancers require the hormone testosterone for cell growth. Testicles make all the testosterone in men. 2 adrenal glands also create a smaller amount of testosterone.

Enzalutamide is especially the androgen receptor (AR) inhibitor, which would easily enable the threefold inhibition across androgen.

It would be automatically signaling the pathway even without creating the AR agonist activity.

Before taking the medication, it is quite essential to know how long does enzalutamide work for.

Enzalutamide especially inhibits the androgen binding with receptors, interacts with chromosomal DNA, and even makes androgen receptor nuclear translocation.

These would automatically up-regulate Oncogenes with extensively 1,2 Enzalutamide binding AR to 5 to 8-fold affinity.

Normally, the first-generation Antiandrogens like Bicalutamide and 2-3 folds would reduce the affinity compared to natural Ligand Dihydrotestosterone.

Molecular docking especially involves Enzalutamide Binding Ligand binding along with the AR inhibitor.

Enzalutamide comes under the class of medications called as Androgen Receptor inhibitors.

These perfectly work with easily blocking effects of androgen, which is a male reproductive hormone.

Check the enzalutamide cost online from Grant pharmacy before buying the medicine, as it can save you money.

The medicine is also a suitable option for stopping the growth and spread of cancer cells.

How to Use Enzalutamide?

This section provides general information about common ways of using the medication. Your personal directions may differ depending on your condition and treatment regimen.

• Take enzalutamide once per day approximately at the same time.
• The medication can be consumed with or without food.
• Swallow the capsule or tablet whole and with enough water.
• Do not chew, disintegrate or open the capsules. Do not cut, crush or chew the tablets.
• Use the medication as long as prescribed by your oncologist. Do not change the dosage or stop taking the medicine without consulting your physician.
• Inform your doctor about your history of seizures, stroke, brain injuries, cardiovascular disorders, and falls.
• Call your doctor immediately in case of occurrence of the seizures, loss of consciousness, severe confusion, acute visual disturbances, and signs of allergic reactions.
• In case of development of the adverse effects, your doctor may suspend the treatment or reduce the dose.
• The men, who are using the contraceptive methods of their partners who can become pregnant, need to use the efficient contraceptives during the treatment of the condition and after it in accordance with the recommendations from the labeling.

The information provided above is general in its nature and cannot substitute professional medical advice. Always follow the recommendations from your health care provider.

Indications/ Usage

Enzalutamide is an androgen receptor inhibitor that is prescribed in cases of specific types of prostate cancer. Enzalutamide can be prescribed in cases of castration-resistant prostate cancer (CRPC), metastatic castration-sensitive prostate cancer (mCSPC), and non-metastatic castration-sensitive prostate cancer with biochemical recurrence at high risk for metastasis in the current labeling of the drug in the United States. 

Enzalutamide affects several stages of the androgen receptor signalization by inhibiting androgen binding to the androgen receptor and interfering with transport of the receptor to the nuclei and interaction with DNA. This leads to the suppression of the androgen-induced proliferation of prostate cancer cells.

During the treatment of the CRPC and mCSPC with enzalutamide, the patients receive treatment with the gonadotropin-releasing hormone (GnRH) analogs, except for the patients with the history of bilateral orchiectomy. In case of the high-risk biochemical recurrence in some patients, treatment can be conducted both with and without the GnRH analogs.

Contact your doctor in case of persisting symptoms or lack of desired effects.

Patient-Centered Care at Grant Pharmacy

At Grant Pharmacy, we are committed to providing patient-centered care to individuals undergoing treatment with Enzalutamide. Our team of pharmacists is dedicated to supporting patients every step of the way, from medication management to emotional support and encouragement.

Missed Dose:

Take the Enzalutamide medicine as soon as you remember the dosage. Whether it is time for the next dosage then you need to skip the missed dose and go back on the regular schedule.

You must not be taking the missed dose along with the present dosage. Overdose could be causing various side effects.

Overdose:

Whether you have accidentally overdosed on the medicine, then you need to seek emergency medical attention immediately. Sometimes, the overdose could be causing the seizure in the body.

Usual Dosage

The dosage depends on the condition, age, weight, organ functions and individual response to treatment.

Common recommendations in the prescribing information are: usual adult dosage of enzalutamide is 160 mg taken orally once per day, with or without food, continued until disease progression or intolerance. Current formulations in the United States contain 40 mg capsules and 40 mg or 80 mg tablets.

If a patient experiences Grade 3 or intolerable adverse event, the treatment needs to be suspended for approximately one week or until recovery of the symptoms, and resumed at the same dose or with reduced dosage of 120 mg or 80 mg once per day, in accordance with the clinical situation.

In case if the usage of the strong CYP2C8 inhibitor is unavoidable, the current labeling recommends to reduce the dosage of enzalutamide to 80 mg once per day. The strong CYP3A4 inducers should be usually avoided, but in case if they cannot be avoided, there is detailed information about the necessary dose adjustment in the labeling.

The physician will choose the most appropriate dose and regimen for your condition.

Precautions and Warnings:

Before taking the Enzalutamide, it is essential to know about the precautions to be followed. Knowing how long xtandi does stay in your system is essential for getting the full effect.

Normally, Xtandi results in median metastasis-free survival time. Many chemotherapy drugs will be cleared from body waste within 2 days.

Talk to your doctor whether you are taking prescription and nonprescription medications, nutritional supplements or vitamins. The doctor would suggest the right dosage of the medicine to get the full effect.

Talk to your doctor when you are taking the following medicines such as

• Anticoagulants like Warfarin (Coumadin, Jantoven)
• Carbamazepine (Carbatrol, Equetro, Tegretol, Others)
• Ergotamine (Migergot, Cafergot)
• Clopidogrel (Plavix)
• Cyclosporine (Gengraf, Neoral, Sandimmune)
• Dihydroergotamine (D.H.E. 45, Migranal)
• Fentanyl (Actiq, Duragesic, Fentora, Subsys, Others)
• Omeprazole (Prilosec)
• Itraconazole (Onmel, Sporanox)
• Gemfibrozil (Lopid)
• Midazolam
• Phenytoin (Dilantin, Phenytek)
• Rifabutin (Mycobutin, In Talicia)
• Rifampin (Rimactane, In Rifamate, In Rifater)
• Pimozide (Orap)
• Sirolimus (Rapamune)
• Rifapentine (Priftin)

Talk to your doctor when you are taking the herbal products for St. John's Wort or others.

Talk to your doctor when you have had surgery, such as dental surgery, and have been taking the enzalutamide.

Whether you like to know ‘how much does xtandi cost,’ then you can find better options for purchasing Grant online Pharmacy.

Talk to your doctor when you have been taking the medication for various treatments or have a medical history of

• High blood pressure
• Seizures
• Risk factors for seizures (Brain Injury, Stroke and Brain Tumor)
• Heart Disease (such as angina/chest pain, heart attack),
• High Cholesterol or Fats (Triglycerides)
• Diabetes
• Falls
• Broken bones

Side Effects of Enzalutamide:

The common side effects of the medication are:

• Feeling of tiredness or weakness
• Pain in back
• Arthralgia and myalgia
• Flushes
• Hypertension
• Diarrhea
• Hyporexia
• Headache
• Dizziness
• Falls

The serious side effects are seizures, posterior reversible encephalopathy syndrome (PRES), ischemic heart disease, falls and fractures, and severe hypersensitivity reactions. Seizures were observed in a small percentage of patients who received enzalutamide and the risk of their development is higher in patients with predisposition factors. Enzalutamide needs to be permanently discontinued in case of occurrence of the seizures.

Since falls and fractures can occur during the treatment, patients should be evaluated for the risk of falls and fractures, especially when additional risk factors for the osteoporosis are presented.

These side effects are usually mild and temporary. Consult your physician if any of them become bothersome or persist longer than expected.

Storage:

Store the Enzalutamide tablets at the temperature between 68°F to 77°F or 20°C to 25°C

Keep Enzalutamide tablets dry

Keep the medicine in a tightly closed container

Interactions:

Normally, Drug Interaction could change the effectiveness of the medication in the body. These could be leading to risky side effects, so it is best to check the drug interaction level.

Enzalutamide also interacts with certain drugs. Talk to your doctor about whether you are taking the medicine for various health issues.

You must not start or stop the dosage of Enzalutamide without consulting the doctor. Below is the list of the medicines that Enzalutamide interacts with

• John's Wort - herb inducing CYP3A4 Metabolism of enzalutamide
• Seizure medications (phenobarbital, phenytoin)
• 1,2-Benzodiazepine (serum concentration of 1,2-Benzodiazepine decreased if combined with Enzalutamide)
• Abatacept
• Abacavir (may decrease the excretion rate of Enzalutamide)
• Abametapir (Serum concentration of Enzalutamide increased if combined with Abametapir)
• Abemaciclib (Serum concentration of Abemaciclib decreased if combined with Enzalutamide)
• Ergot Alkaloids (Dihydroergotamine, Ergotamine)
• Pimozide
• Sirolimus
• Voriconazole
• Tacrolimus
• Suvorexant
• Asunaprevir
• Cobicistat

At Grant Pharmacy, we are dedicated to providing comprehensive support and personalized care to individuals undergoing treatment with Enzalutamide.

Drug Interactions

Enzalutamide has significant potential of drug interactions. Strong CYP2C8 inhibitors can cause the increased exposure of enzalutamide and require reduction of the dose. The strong CYP3A4 inducers, such as rifampin, can decrease enzalutamide and metabolites' exposure and efficacy of the therapy.

Enzalutamide itself is the strong CYP3A4 inducer and moderate CYP2C9 and CYP2C19 inducer, so it can cause reduction of the blood levels of other medicines metabolized in such ways. This interaction requires particular attention in case if the reduction of the concentration of the interacting medicine can result in the inefficacy of the treatment.

In the current labeling of enzalutamide it was noted that this medicine can interfere with certain digoxin immunoassays and may lead to false elevations of digoxin blood test results. The laboratory should know that the patient uses both enzalutamide and digoxin.

Inform your doctor and pharmacist about all medicines, supplements and herbal products that you are taking before initiation of the treatment.

Frequently Asked Questions about Enzalutamide (FAQs)

Is Enzalutamide A Chemotherapy Treatment?

No, Enzalutamide is not involved with chemotherapy, but it is used for treating cancer cells. These are hormone therapy that works on preventing the growth and spread of prostate cancer cells.

What Is The Function Of Enzalutamide Medicine?

Enzalutamide has the androgen receptor blocker (inhibitor), which blocks testosterone from reaching the Prostate cancer cells. Enzalutamide can also slow the growth of cancer cells, and it could automatically shrink them.

How Long Can I Take Enzalutamide?

Taking the enzalutamide for a longer time could be controlling the cancer cells. Consult with the doctor about the prescription to get the full effect.

When Is The Best Time To Take Enzalutamide?

The patient needs to take Enzalutamide at the same time each day. It is important to swallow the Tablet or capsule as a whole, with or even without food. Whether you are having hormone therapy before taking this medicine, then you can continue it.

Does Enzalutamide Affect Memory?

There are reports stating the high dosage of enzalutamide can lead to memory impairment and anxiety. But these do not deal with the abiraterone acetate.

Medically reviewed by the Grant Pharmacy Pharmacists Medical Team

Medical References

DailyMed – XTANDI (Enzalutamide) Capsules and Tablets, Full Prescribing Information, Effective July 28, 2026
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b129fdc9-1d8e-425c-a5a9-8a2ed36dfbdf

MedlinePlus – Enzalutamide
https://medlineplus.gov/druginfo/meds/a612033.html