Alerfix Total

Alerfix Total

Introduction

Alerfix total consists of Levocetirizine Hydrochloride 5 mg, montelukast 10 mg, and Ambroxol Hydrochloride 75 mg sustained release. The verified alerfix total composition has been obtained from official pricing documentation of the marketed formulation.

Levocetirizine is an antihistamine medicine, montelukast is a leukotriene receptor antagonist, and ambroxol is a mucus-clearing medicine for respiratory problems and allergy treatment. The combination of these three substances is meant to help in treatment of respiratory diseases in presence of allergic reactions.

What is Alerfix Total

The formula for alerfix total involves three drugs namely: levocetirizine hydrochloride, montelukast sodium 10 mg and sustained release of ambroxol hydrochloride 75 mg.

The use of levocetirizine dihydrochloride 5mg aims at histamine H1 receptor antagonism. The montelukast sodium 10 mg acts as a CysLT1 antagonist. The ambroxol reduces the viscosity of mucus.

Thus, Alerfix Total is distinct from regular antihistamine medicine because it contains antiallergic properties of montelukast.

How It Works

Levocetirizine acts as a histamine H1 receptor antagonist. The main function of histamine is to cause sneezing, nasal discharge, skin irritation, watering eyes and others. From the information provided by the manufacturer of this medication, it is generally a dose of 5 mg of levocetirizine dihydrochloride tablet that is prescribed for adult antihistamine patients.

Montelukast sodium 10 mg inhibits leukotriene receptors for causing inflammation in the airway passage.

Ambroxol works as a secretolytic agent. It facilitates movement of secretions from the airways and helps to expel thick mucus.

Why It Is Prescribed

This medicine may be prescribed in case of occurrence of allergy along with respiratory mucus and airway-related conditions. In addition, Alerfix Total is indicated for treatment of the combination of allergic rhinitis and productive cough and respiratory disorders, which can include thick mucus.

Levocetirizine is used separately in cases of allergic rhinitis and urticaria.

In selected adult patients who suffer from asthma and who are already receiving asthma treatment, montelukast can be used to relieve symptoms of seasonal allergic rhinitis.

Moreover, it is also used to relieve seasonal allergic rhinitis in adult patients suffering from asthma. Ambroxol works to remove thick respiratory secretions.

How to take this medication

These tab alerfix total should be taken strictly in accordance with prescription, which you will receive from a doctor. Take out a tablet from its packaging and take it with a glass of water. As this tablet contains a sustained-release formula of ambroxol, it should not be broken, chewed or altered, unless it is specified explicitly in the instructions for this particular product.

Usually, levocetirizine and regular montelukast tablets can be taken with or without food; however, it is better to follow the prescription in any case.

Try to take the dose at the same time every day, and do not take the medicine additionally in case of troubling symptoms, and do not take it along with the medicines containing levocetirizine, montelukast, or ambroxol tablet without the consultation of your physician.

How It Works Inside the Body

Levocetirizine is absorbed quite quickly after oral administration and is minimally metabolized. Renal elimination of this medicine is significant for levocetirizine, which makes renal function important for proper treatment assessment.

Montelukast sodium 10 mg is absorbed via the gastrointestinal tract and metabolized extensively. It acts selectively on cysteinyl leukotriene receptors.

After the absorption ambroxol enters respiratory tissues where it facilitates clearing of the mucus. Sustained-release tablets release ambroxol gradually into bloodstream.

Dosage Explanation

Each Alerfix total tablet contains levocetirizine 5 mg, montelukast 10 mg, and ambroxol hydrochloride 75 mg. Dosage should be determined depending on prescription in case of this particular fixed dose combination.

The general recommended dose of levocetirizine 5 mg is once daily for adults and adolescents aged over 12 years.

Regular montelukast sodium 10 mg is prescribed once daily for adults and adolescents over 15 years of age with corresponding asthma indication.

Sustained-release ambroxol 75 mg should not be separated to be used by children. Pediatric treatment with this formulation requires different dosage form.

What to Expect During Treatment

As levocetirizine starts its action, patients may experience disappearance of such allergic symptoms like sneezing, runny nose, itchiness of skin, eyes and others. In addition, levocetirizine can begin its antihistamine action in about an hour.

Montelukast allows maintaining the leukotriene-mediated respiratory inflammation under control but it is not used as a bronchodilator to treat asthma attacks.

With continued ambroxol treatment, removal of thick mucus becomes easier for patients. The productive cough should not disappear immediately because it can assist in removing loosened respiratory mucus.

However, breathing difficulties that persist, the worsening of the cough, or lack of the symptom improvement need further medical evaluation.

Side Effects

Such mild side effects as:

• sleepiness – levocetirizine can cause it in some patients
• headache – can be caused both by levocetirizine or montelukast
• dryness of the mouth – rare effect of levocetirizine
• nausea – can happen during combined treatment
• abdominal pain – sometimes happens.

Commonly discussed ambroxol side effects can include nausea. If side effects persist, it is necessary to consult a physician. Changing of a dose cannot resolve them.

Drug Interactions

Exposure to montelukast can change due to interaction with drugs that increase or reduce montelukast exposure. Phenytoin, phenobarbital, and rifampicin can decrease the exposure while some other medicines can increase the exposure of montelukast.

There is limited metabolic interaction possibility with levocetirizine. But it is possible to increase the sedation, if levocetirizine is taken together with something else that influences the level of alertness of a person.

In addition, the patient should inform the healthcare provider about all medicines he uses, both prescription ones and non-prescription.

This medicine should not be used simultaneously with levocetirizine, montelukast or ambroxol in case, if another medicine is not prescribed by a doctor.

Alerfix Total vs Alternative Treatments

Alternative treatment methods depend on the primary symptoms. The allergic rhinitis can be treated only with antihistamine medicine, such as levocetirizine. Asthmatics, who need asthma control medicine, may be prescribed montelukast in addition to asthma medications.

Sometimes treatment of the mucus production in respiratory system needs only mucolytic or expectorant. Sometimes treatment requires both an antihistamine medicine and a leukotriene antagonist.

The search query cloxan ambroxol does not describe the verified composition of Alerfix Total. The composition of the marketed formulation consists of levocetirizine, montelukast and ambroxol, not of cloxan.

Precautions and warning

Inform the healthcare provider about your renal disease before treatment because renal function affects levocetirizine clearance greatly. The dose and dose interval might require modification in the case of renal impairment.

It is not possible to use montelukast sodium during an acute asthma attack. Asthma sufferers should continue using rescue medicine along with their controller therapy unless the treatment has been changed by a physician.

Patients taking montelukast should monitor their mood and behavior because of neuropsychiatric reports in connection with montelukast.

Before the treatment you should tell your healthcare provider everything about pregnancy, breast-feeding, renal or liver disorders, and about all drugs, you use now.

The levocetirizine dogs dosage is related to the veterinary medicines. This human combination contains three medicines and is not to be prescribed to dogs on the basis of human dose recommendations.

Cost and Affordability

The alerfix total tablet price will depend on the quantity of pills, pharmacies, geographical location, taxes, etc. Official pricing documentation confirms the marketed formulation consisting of 5 mg/10 mg/75 mg, while retail price can vary over time.

People, who are interested in this medicine, may check its actual price with Grant Pharmacy online and purchase it there if it is applicable and legal.

Remember always to compare the exact three-component formulation, tablets, amount and the price, not the prices of Alerfix M or some of its components.

Practical Tips for Better Results

It is important to take Alerfix Total strictly following prescription. Follow the special instructions about taking the sustained-release pill. Drink enough of liquid unless there is some restriction to it.

Avoid independent use of another ambroxol pill, antihistamine or montelukast-containing medicine along with Alerfix total.

In case of asthma, continue using inhalers because Alerfix total cannot substitute emergency treatment or asthmatics controller medicine.

Storage Instruction

It is required to store this medicine in compliance with storage directions indicated on its packaging. Keep it from excess moisture, high temperatures and any other factors of environment that could affect it negatively.

Keep all medicines in their initial containers so their strength and expiration date remained visible. It is important to store all medicines safely far away from children. Don't use expired tablets.

FAQs

1. What is the composition of Alerfix Total?

Alerfix Total consists of levocetirizine hydrochloride 5 mg, montelukast sodium equivalent to 10 mg and ambroxol hydrochloride 75 mg sustained release. Such combination provides antihistamine, leukotriene receptor antagonist, and mucus-thinning activities within a tablet.

2. What is Alerfix Total used for?

It can be prescribed in case of appearance of allergy accompanied by respiratory mucus or breathing problem. This medicine is used in case of allergic rhinitis and productive cough because of three components addressing three problems mentioned above.

3. What does ambroxol do in Alerfix Total?

Ambroxol is a mucolytic and secretolytic medicine. It helps to loosen thick respiratory mucus and allows getting rid of mucus easier in case of productive coughing. The fixed combination of Alerfix Total contains 75 mg of ambroxol hydrochloride in the sustained-release form.

4. What is the role of montelukast in Alerfix Total?

Montelukast is a leukotriene receptor antagonist blocking CysLT1 receptors associated with airway inflammation. Alerfix Total contains 10 mg of montelukast, which is the dose that can be used by adults. Montelukast cannot work as quick-relief bronchodilator for asthma.

5. Does Alerfix Total cause sleepiness?

As it was mentioned, levocetirizine can have such side effect as somnolence or fatigue, decreased alertness in some patients. Those patients who have such side effect should avoid driving, cycling and using any machines until full restoration of alertness and consulting of a physician.

6. Can Alerfix Total be given to children?

As this fixed combination includes the adult dosage of montelukast and sustained-release ambroxol along with levocetirizine, it shouldn't be split or modified for children. In order to prescribe the correct medicine, pediatrician should evaluate children's health.

7. Can Alerfix Total replace an asthma rescue inhaler?

No. Montelukast cannot replace asthma rescue inhaler because it is a controller medicine, not a quick-acting bronchodilator. Montelukast cannot be used as a replacement of the prescribed rescue inhaler for asthma.

Final Conclusion

Alerfix Total is a combination medicine with such components as Levocetirizine Hydrochloride 5 mg, Montelukast 10 mg and Ambroxol Hydrochloride 75 mg Sustained Release.

Combination contains antihistaminic, leukotriene antagonist and secretolytic medicines.

Levocetirizine controls allergic reactions, montelukast sod 10 mg acts against leukotriene-mediated inflammatory processes in the respiratory system, ambroxol decreases the mucus viscosity.

As combination contains three active medicinal substances, it is better to follow only prescription of the tablet.

 

Medically reviewed by the Grant Pharmacy Pharmacists Medical Team

Medical References

Official Manufacturer Information – Levocetirizine 5 mg Film-Coated Tablets, Summary of Product Characteristics
https://www.medicines.org.uk/emc/product/9917/smpc

Official Manufacturer Information – Levocetirizine Dihydrochloride 5 mg Film-Coated Tablets, Summary of Product Characteristics
https://www.medicines.org.uk/emc/product/10887/smpc

Official Manufacturer Information – Montelukast 10 mg Film-Coated Tablets, Summary of Product Characteristics
https://www.medicines.org.uk/emc/product/13555/smpc

Official Manufacturer Information – Montelukast 10 mg Film-Coated Tablets, Summary of Product Characteristics
https://www.medicines.org.uk/emc/product/9918/smpc