Trioday (Lamivudine + Tenofovir + Efavirenz )

Lamivudine 300mg + Tenofovir Disoproxil Fumarate 300mg + Efavirenz 600mg

What is Lamivudine 300mg + Tenofovir Disoproxil Fumarate 300mg + Efavirenz 600mg? 

Lamivudine + Tenofovir Disoproxil Fumarate + Efavirenz is the best supplement to treat HIV infection. This medicine is approved by the U.S. FDA for AIDS infection treatment. 

The brand name of efavirenz + lamivudine + tenofovir disoproxil fumarate tablet Symfi. This medicine is suitable for children and adults with 40 kg weight. 

This medicine cannot cure AIDS, but it aids the person with AIDS to live longer. It helps to lessen the risk of AIDS/HIV transmission. 

Before taking efavirenz 600 mg, you should consult with a healthcare professional. You can take this supplement until the doctor tells you to stop them for a better result. 

The person should not take this medicine with other AIDS capsule that causes some side effects. 

Lamivudine + Tenofovir Disoproxil Fumarate + Efavirenz capsule can cause adverse effects such as liver problems, kidney failure, development of lactic acid in the blood, mental health issues, 

At Grant Pharmacy, we are proud to introduce a triumphant trio in the fight against HIV: Lamivudine 300mg + Tenofovir Disoproxil Fumarate 300mg + Efavirenz 600mg. This potent combination therapy not only suppresses viral replication but also empowers individuals to reclaim their health and vitality.

Before adding this medicine to your diet, please check the guidelines for lamivudine use in adults. Some problems will go automatically if the body sets to the medication. 

Those who are experiencing the severe side effects can consult the doctor. Severe side effects are unusual muscle pain, tiredness, dizziness, abnormal heartbeat, stomach pain with vomiting, and more. 

You can check the tenofovir cost from different Grant online pharmacy and purchase an affordable one to treat the HIV infection. 

If the person has HBV and AIDS and takes this medication, the infection might get worse when they stop taking this tablet. Therefore, the individual should not stop taking Efavirenz without asking the physician. 

Continue reading the post to learn about the Lamivudine + Tenofovir Disoproxil Fumarate + Efavirenz medicine, such as how does tenofovir work, its side effects, how to use and others. 

How does Lamivudine 300mg + Tenofovir Disoproxil Fumarate 300mg + Efavirenz 600mg work? 

Tenofovir disoproxil fumarate + Efavirenz + Lamivudine is a blend of three antiviral medicines that works effectively to prevent AIDS from spreading. 

Efavirenz is called a NNRTI and Lamivudine and tenofovir are known as NRTI. These three medicines are not a cure for AIDS infections. 

These medicines help lessen the virus in the body and boost the CD4 cells in the blood, safeguarding against the HIV disease. 

The tenofovir disoproxil not only reduces the chance of getting the AIDS complication but also enhances the life quality. 

If you take this medicine correctly as prescribed by the healthcare professional, it helps to reduce the HIV infection spreading. You can utilize efficient barrier methods during sexual activities. 

People with HIV infection never share personal items like toothbrushes, needles, or combs with others. These items can spread AIDS infections. 

How to use Lamivudine 300mg + Tenofovir Disoproxil Fumarate 300mg + Efavirenz 600mg? 

This information describes the usage pattern of the given drug in general terms and is subject to change from case to case.

• Trioday is to be taken once per day as recommended by a health care practitioner.
• This medicine must be administered on an empty stomach either one hour before or two hours after the meals.
• The administration of the medicine before going to sleep will lessen the adverse neurologic reactions of efavirenz (headache, difficulty sleeping, vivid nightmares etc.).
• Take the medicine regularly every day approximately at the same time.
• Do not suspend the treatment or skip its doses without consulting a physician; it leads to HIV resistance.
• A test of kidney function (such parameters as serum creatinine, estimated creatinine clearance, glucose and proteinuria, serum phosphorus are to be controlled) is to be performed prior to and during therapy.
• Liver functioning should also be checked periodically, especially in patient who has any kind of liver disease or HBV infection.
• If severe depression, suicidal ideation, extreme mental confusion or other psychiatric disorders occur, you must immediately inform a physician.
• In case of missing a dose, you should use it unless a second dose is near. You should never use two doses at once.

This information is of general character and cannot be regarded as professional consultation. Always follow the recommendations of your health care practitioner.

Indications/ Usage

Trioday includes efavirenz, lamivudine, and tenofovir disoproxil fumarate – a triple antiretroviral therapy that can be used as a single regimen for the treatment of HIV-1 infection in appropriate patients aged 40 kg or above.

The conventional dosing form includes efavirenz 600 mg, lamivudine 300 mg, and tenofovir disoproxil fumarate 300 mg.

The first constituent, efavirenz, is a non-nucleoside reverse transcriptase inhibitor (NNRTI). The other two – lamivudine and tenofovir are the nucleoside/nucleotide reverse transcriptase inhibitors that suppress HIV reproduction and reduce its load. Therapy helps restore the functions of immune system but does not cure HIV itself.

Prior to the beginning of therapy, patient must be tested for the presence of hepatitis B infection because this drug inhibits the reproduction of this virus. The termination of this treatment in HIV-infected patient who also has hepatitis B causes a significant worsening of his/her state.

Inform the doctor about persisting symptoms and inefficiency of therapy.

Missed dose 

Take the missed dose quickly when you remember if you miss a lamivudine dose. If it is time for the next dosage, you can skip the missed dose and continue the regular schedule. 

Don't take double doses of this medication because it causes some side effects.

Overdose

Avoid taking an overdose of efavirenz that causes severe side effects. It includes trouble breathing, passing out, skin loosening, dry mouth, bone pain, and more. 

You should contact the healthcare professional or hospital for immediate treatment if anyone has severe symptoms. 

Usual Dosage

Dosage is determined depending on condition, age, weight, liver/renal function and reaction to treatment.

The usual recommendation for adults and children aged 40 kg or above is the intake of one tablet daily on an empty stomach. The tablet should be used preferably before going to sleep. The standard tablet includes efavirenz 600 mg, lamivudine 300 mg, and tenofovir disoproxil fumarate 300 mg.

As this fixed-dose combination cannot be separated into its ingredients which should not be modified individually, this drug is contraindicated in case when creatinine clearance is below 50 mL/min or patient has end-stage renal disease which needs hemodialysis.

This fixed-dose combination is contraindicated in patients with moderate and severe hepatic impairment (Child-Pugh B/C), whereas patients with mild hepatic insufficiency should use this drug with precaution.

The most appropriate dose and therapy scheme will be defined by a doctor.

Precautions and warnings 

If you have any allergic component in this medicine, you must inform the doctor before taking Efavirenz/Lamivudine/Tenofovir disoproxil fumarate capsule. 

If the product has any inactive components, it can cause allergic reactions. 

The healthcare professional can regularly check the patient's progress for the first few weeks after taking this tablet. 

If the person experiences any unwanted side effects, the healthcare professional will check the urine and blood tests. 

Pregnant and breastfeeding women never take this supplement, which can harm the growth and health of the baby.

Avoid driving vehicles and operating heavy machines after taking this capsule because it causes sleepiness and dizziness. 

Don't skip this medicine that enhances the risk of treatment failure. So, it would help if you took it properly at the regular schedule. 

The lamivudine cost is lower in the Grant online pharmacy than in the physical store. So you can order this medicine online to treat the HIV infection. 

This medicine can cause bones to weaken, so you can take calcium and vitamin D supplements and work regularly as the doctor advises.

Availability at Grant Pharmacy

Lamivudine 300mg + Tenofovir Disoproxil Fumarate 300mg + Efavirenz 600mg combination therapy is available at Grant Pharmacy, where patients can access high-quality medications and receive personalized care from experienced pharmacists.

Side effects of Lamivudine 300mg + Tenofovir Disoproxil Fumarate 300mg + Efavirenz 600mg

The common side effects of Trioday are:

• Dizziness
• Headache
• Insomnia
• Vivid and abnormal dreams
• Sleepiness
• Hardly concentrating
• Nausea
• Diarrhea
• Rash
• Tiredness

Neurological symptoms caused by efavirenz occur most frequently at the beginning of the treatment and become less disturbing after some time.

These side effects are normally transient and mild. If side effects bother you or last for too long time, consult your doctor.

Storage

Store the tenofovir 300 mg at room temperature 

Keep them out of pets and children reaches.

Store this medicine away from moisture and direct sunlight

Store Tenofovir Disoproxil Fumarate medicine in the container and close them tightly

Never flush expired capsules down the toilet. 

You can consult a doctor or local disposal company to dispose of the medicine safely.

Interactions 

Drug interaction might change the working function of this medication. It can also enhance the risk of severe side effects. 

You should prepare the list of products, prescribed and non-prescribed supplements, and inform the healthcare professional. 

The doctor suggests the right medicine after analyzing the patient's medical history.

Without consulting with the physician, you don't change the dosage or stop this medicine.

Some products may interact with tenofovir, such as 

• Orlistat
• Sorbitol
• Adefovir
• Aminoglycosides 
• Ombitasvir
• Paritaprevir
• Ritonavir
• Dasabuvir

Also, you don't take this tablet with other HIV medication that causes severe side effects. Avoid products that contain the following components. 

• Lamivudine 
• Tenofovir 
• Efavirenz 

Be careful when taking Lamivudine 300mg + Tenofovir Disoproxil Fumarate 300mg + Efavirenz 600mg; it helps to reduce side effects and reduce the spreading of HIV infections.

Drug Interactions

Efavirenz alters the metabolism of many drugs, thus, there are plenty of interactions between this medication and other prescription medicines. Fixed-dose combination is contraindicated for the combination with the medicines elbasvir and grazoprevir as efavirenz reduces their concentration significantly and makes their activity inadequate.

Medicines that have damaging effects on kidneys can provoke kidney dysfunction as a consequence of using this drug. It is essential to check whether the patient uses concurrent or recent nephrotoxic medicine.

There are numerous medicines which can interact with efavirenz (anticonvulsants, antimycobacterial medicines, antifungals, hormonal contraceptives and antiretroviral medicines). St. John’s wort is among the medicines that may also have interaction with Trioday.

This medicine must not be taken alongside with another one which already has efavirenz, lamivudine or tenofovir disoproxil fumarate.

Let your doctor and pharmacist know all about the medicines you use.

Frequently asked questions about Lamivudine 300mg + Tenofovir Disoproxil Fumarate 300mg + Efavirenz 600mg (FAQs)

What is Lamivudine 300mg + Tenofovir Disoproxil Fumarate 300mg + Efavirenz 600mg?

Efavirenz/Lamivudine/Tenofovir disoproxil fumarate is the best medication to treat HIV or AIDS infections. 

This medication is suitable for adults and children with forty kilograms. If you take this supplement accurately as prescribed by a doctor, you can get a better outcome. 

The person can save the trioday price by ordering this medicine online from Grant Pharmacy. 

What are the common side effects of Lamivudine 300mg + Tenofovir Disoproxil Fumarate 300mg + Efavirenz 600mg?

Discouragement, lack of appetite, anxiety, fever, trouble sleeping, rashes, and irritability are the common tenofovir side effects.

You consult the physician before consuming Efavirenz/Lamivudine/Tenofovir disoproxil fumarate without consulting the physician. The doctor suggests the correct dosage and duration according to your health condition.

How long does tenofovir stay in the body?

How long does tenofovir stay in your body is a common question. Tenofovir can remain in the body for up to seventy hours. 

Medically reviewed by the Grant Pharmacy Pharmacists Medical Team

Medical References

DailyMed – Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate Tablets
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?audience=consumer&setid=1f8f9fe1-b8fd-4f65-8832-9d3d6802d076

DailyMed – Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate Full Prescribing Information
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=1f8f9fe1-b8fd-4f65-8832-9d3d6802d076

MedlinePlus – Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate
https://medlineplus.gov/druginfo/meds/a618028.html